Frequently Asked Questions about Spravato
What is Spravato?
Spravato (esketamine) is a groundbreaking FDA-approved treatment for individuals struggling with treatment-resistant depression (TRD) or major depressive disorder (MDD) with suicidal thoughts or behaviors. It is a nasal spray formulation of esketamine, a derivative of ketamine, and is designed to work differently from traditional antidepressants. Unlike conventional antidepressants that primarily target serotonin, dopamine, and norepinephrine, Spravato acts on the glutamate system, the brain's most abundant neurotransmitter. This unique mechanism promotes rapid neural repair and synaptic growth, effectively rewiring brain circuits involved in depression.
This is why many patients report feeling significant improvements within hours or days, rather than waiting weeks or months for relief. This treatment is not just about managing depression—it’s about providing a pathway to recovery for individuals who have felt stuck, hopeless, or exhausted by the limitations of traditional therapies. The process to get started is simple, with most insurance plans covering treatment for eligible patients. If you or a loved one has been struggling with depression despite trying multiple medications, Spravato may be the life-changing solution you’ve been waiting for.
Who is a good candidate for Spravato?
If you have been battling depression and have tried at least two antidepressants without success, Spravato may be the game-changer you’ve been looking for. It is designed for individuals who feel stuck in their current treatment and need a new approach to reclaim their lives. Spravato is also an option for those experiencing suicidal thoughts, providing rapid relief when it is needed most.
A consultation with a provider can help determine if this treatment is the right fit for you.
Is Spravato safe?
Spravato is FDA-approved and has undergone rigorous clinical trials to ensure its safety and effectiveness. It is administered under medical supervision in a calm, supportive environment to ensure the best possible experience. Because it can cause mild dizziness or temporary disconnection from reality, patients are monitored for a short period after each session before returning home.
How soon will I see results?
One of the most exciting aspects of Spravato is how quickly it can work. Many patients report noticeable improvements in their mood and mental clarity within hours of their first session. While results vary, clinical studies have shown that many individuals experience a significant reduction in depressive symptoms within the first two weeks. This means you don’t have to wait months to feel better—relief may be just around the corner.
How long do the effects of Spravato last?
The effects of Spravato can last for weeks or even months, depending on the individual. During the initial phase, treatments are scheduled twice per week for the first month, followed by once-weekly or biweekly sessions. This structured approach helps ensure long-term benefits while giving your brain time to adjust and heal.
Can I return to work or drive after treatment?
Because Spravato can cause temporary dizziness or drowsiness, it is required that patients arrange for a ride home after treatment. Most patients feel back to normal within a few hours, but to ensure safety, driving and operating machinery should be avoided for the rest of the day.
Does Spravato hurt or is it painful?
Spravato is completely painless. It is a nasal spray, so there are no needles, IVs, or invasive procedures involved. Some patients report a mild tingling sensation in the nose, but this is temporary and fades quickly.
What happens if Spravato does not work for me?
Spravato has been life-changing for many, but if it doesn’t provide the relief you need, there are always other options. Your provider will work closely with you to explore alternative treatments, such as transcranial magnetic stimulation (TMS), or medication adjustments. Mental health treatment is highly personalized, and there is always hope.
What is the difference between Spravato(esketamine) and IV/IM Ketamine
Both Spravato and IV ketamine are powerful treatments for depression, but they have some KEY differences. Spravato is a nasal spray that is FDA-approved for treatment-resistant depression and must be administered in a certified treatment center.
IV/IM or oral ketamine, on the other hand, is NOT FDA-approved for depression. Many patients find Spravato to be a convenient and insurance-friendly option, as it is COVERED by most major insurance providers.
How much does Spravato cost? Is it covered by insurance?
Spravato is covered by most major insurance plans, including Medicare, if you meet the criteria for treatment-resistant depression. Out-of-pocket costs will depend on your specific insurance plan, but many patients only pay a small co-pay per session. There are also financial assistance programs available to help reduce costs, making this treatment accessible to those who need it. Our team can assist with verifying your coverage and exploring affordability options.
Are there side effects associated to Spravato therapy?
Like any medication, Spravato has some potential side effects. The most common ones are mild and temporary, including dizziness, nausea, increased blood pressure, and dissociation. These effects typically resolve within a few hours. Because treatments are done under medical supervision, any side effects are closely monitored to ensure your safety and comfort.
What do patients usually feel during treatment sessions?
- Most patients describe feeling relaxed, calm, and sometimes even euphoric. Some experience a dream-like sensation or mild dissociation, where they feel detached from their surroundings. This effect is temporary and typically subsides within an hour or two. Many find this part of the treatment to be a unique and even enjoyable experience.
What do patients usually feel after treatment sessions?
- Most patients feel completely fine and resume their normal activities right away.
A mild headache or scalp tenderness may occur, especially after the first few sessions, but usually resolves quickly.
Some patients experience a subtle mood boost after several sessions, though full therapeutic effects may take a few weeks.
Overall, Spravato is well-tolerated, and any discomfort typically decreases over time as patients adjust to the treatment.
How long does Spravato treatment take?
- Each session lasts about two hours from start to finish. The actual nasal spray administration takes just minutes, followed by a monitoring period where you can relax in a comfortable setting. Once your provider determines that it is safe for you to leave, you can go home and resume light activities.
Do I need to stop medication or therapy for Spravato?
No, you can continue taking your current antidepressant while using Spravato. In fact, it is recommended that Spravato be used alongside an oral antidepressant for the best results. Therapy and other mental health treatments can also complement Spravato and enhance your progress.
I don't want to take medication anymore, can I get off them with Spravato?
Spravato has helped some individuals reduce or even discontinue their use of traditional antidepressants. However, medication changes should always be made under the guidance of a healthcare provider. If your goal is to transition off other medications, your provider can create a plan that ensures a smooth and safe adjustment.